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To study aggressiveness of head and neck paragangliomas with superoxide production inside the tumor.

Aggressiveness of head and neck paragangliomas and mitochondrial superoxide production: an observational prospective study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/04/085790
Enrollment
10
Registered
2025-04-28
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D447- Neoplasm of uncertain behavior ofaortic body and other paraganglia

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil

Sponsors

AIIMS New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients with clinicoradiologically diagnosed head and neck paragangliomas 2.Patients giving consent for surgery 3.Confirmation of diagnosis of Paraganglioma postoperatively on histopathological examination.

Exclusion criteria

Exclusion criteria: 1. Patients unfit for surgery under General Anesthesia.

Design outcomes

Primary

MeasureTime frame
Correlation between aggressiveness of HNPGs based on clinical characteristics and amount of superoxide ions produced in tumor cells measured by staining with MitoSOX reagent Timepoint: Intraoperative sample will be preserved and later processed in batches as per availability of MitoSOX dye. Preoperative and post operative status will be assessed one day prior to surgery and on discharge.—

Secondary

MeasureTime frame
To find relationship between aggressiveness and anatomical variant of head and neck paragangliomasTimepoint: ;To find relationship between aggressiveness & anatomical variant of head & neck paragangliomasTimepoint: Intraoperative sample will be preserved & later processed in batches as per availability of MitoSOX dye. Preoperative & post operative status will be assessed one day prior to surgery & on discharge.—

Countries

India

Contacts

Public ContactAgnij Bhattacharyya

AIIMS New Delhi

agnijbhattacharya@gmail.com9547929881

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026