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A clinical study designed to compare the effectiveness of diclofenac and ketoprofen, administered via transdermal and oral routes, in managing pain after root canal treatment.

A comparative evaluation if efficacy of diclofenac and ketoprofen administered using transdermal drug delivery route in management of post endodontic pain: A Randomized Controlled Clinical Trial - NIL

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/085757
Enrollment
40
Registered
2025-04-28
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R52- Pain, unspecified

Interventions

Intervention1: Post Endodontic pain management: Evaluate efficacy of diclofenac (100mg) and ketoprofen (100mg) administered using Transdermal patch for 2 days, each to be applied in the morning after

Sponsors

Narsinhbhai Patel Dental College and Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.)Patients with symptomatic irreversible pulpitis reported discomfort in single-rooted premolar teeth in either jaw. 2.)An intraoral periapical radiograph of selected teeth should exhibit intact lamina dura and no periapical radiolucency. 3.) Teeth with lack of any anatomical challenges, such as canal calcifications, with no foreseen procedural complications.

Exclusion criteria

Exclusion criteria: 1.) Teeth with associated periodontal conditions. 2.) People who have previously experienced adverse responses to diclofenac and ketoprofen or other nonsteroidal anti-inflammatory drugs (NSAIDs), such as bronchospasm, shock, and urticarial. 3.) Patients who had active duodenal or stomach ulcers before 6 months. 4.) Patients receiving NSAIDs or corticosteroids during the study. 5.) People with a history of illnesses such as bronchial asthma, epilepsy, inflammatory bowel disease, severe liver or renal insufficiency, dengue fever, and mental or psychological issues. 6.) Women who are pregnant and breastfeeding. 7.) Patients with a history of receiving antibiotics during the study

Design outcomes

Primary

MeasureTime frame
evaluate and compare the efficacy of two modes of delivery of diclofenac and ketoprofen for postendodontic pain control.Timepoint: 24 hr and 48 hr

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactDr Kailash Attur

Narsinhbhai Patel Dental College and Hospital

atturkailash@gmail.com9727752499

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026