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Finding pain relieving dose of Ketamine,when given with 0.375% Ropivacaine for ultrasound guided erector spinae plane block in spinal surgeries for pain relief

Ketamine as an adjuvant to USG guided Erector Spinae Plane Block with Ropivacaine for Perioperative Analgesia in Lumbar Spinal Surgeries: A Dose-Finding Study - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/085747
Enrollment
108
Registered
2025-04-28
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G55- Nerve root and plexus compressionsin diseases classified elsewhere

Interventions

Intervention1: Bilateral ESP block with Ketamine at a dose of 1mg/kg body weight maximum 50mg: Patients will receive Erector spinae block with 0.375% ropivacaine and Ketamine 1mg/kg body weight(maximu

Sponsors

Institute of Neurosciences Kolkata
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All lumbo sacral surgeries including instrumentation procedures duration upto 4 hours of ASA grade I and II with BMI less than 24

Exclusion criteria

Exclusion criteria: Patient refusal ASA grade III and IV in scoliosis correction surgeries with intraoperative neuromonitoring and revision spine surgery duration more than 4 hours Patient with hypersensitivity to any of drugs in use Patient with congestive heart failure, CAD, chronic kidney disease, hepatic disease, neuropsychiatic disorder, coagulation abnormalities and pulmonary disease

Design outcomes

Primary

MeasureTime frame
Time to request of rescue analgesic in first 36 hours and assessment of duration of analgesic using VAS score at 0 hour,2 hour ,4 hour ,8 hour ,12 hour ,24 hour ,36 hourTimepoint: Time to request of rescue analgesic in first 36 hours and assessment of duration of analgesic using VAS score at 0 hour,2 hour ,4 hour ,8 hour ,12 hour ,24 hour ,36 hour

Secondary

MeasureTime frame
Total intraoperative & postoperative opioid consumptionTimepoint: 36 hours;Intraoperative haemodynamic stabilityTimepoint: 10mins 30mins 1hr 1.5hr 2hr 2.5hr 3hr 3.5hr 4 hr;Occurrence of post operative nausea & vomitingTimepoint: Anytime in first 36 hr

Countries

India

Contacts

Public ContactDr TIYASA PAIN

Institute of Neurosciences Kolkata

kalloldeb15@gmail.com9830028915

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 10, 2026