Health Condition 1: H160- Corneal ulcer
Conditions
Interventions
Intervention1: Antifungal Therapy: Natamycin monotherapy versus Natamycin with Posaconazole.
Follow ups on 3 days, 1 week, 2 weeks, 4 weeks, 6 weeks, 2 months, and 3 months.
Control Intervention1: Ant
Sponsors
L V Prasad Eye Institute
Eligibility
Inclusion criteria
Inclusion criteria: 1.Microbiologically confirmed fungal keratitis (smear and/or culture positive). 2.No prior antifungal use exceeding six times per day for more than 10 days. 3.Corneal infiltrate size 2 6 mm, with stromal involvement not exceeding two-thirds of corneal thickness. 4.Vision in the other eye better than 20/200. 5.Willingness to participate in the study. 6.Non-pregnant individuals. 7.Systemically stable patients. 8.Willingness for admission or regular follow-up.
Exclusion criteria
Exclusion criteria: 1.Mixed infection 2.Participant not willing to participate 3.Having Advanced form of infection 4.Limbal involvement 5.Scleral involvement 6.Posterior chamber involvement
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Number of cases achieving medical cure. 2.Incidence of corneal perforations. 3.Number of patients requiring urgent TPK. Timepoint: 3 days, 1 week, 2 weeks, 4 weeks, 6 weeks, 2 months, and 3 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of patients requiring urgent TPK.Timepoint: 1 week, 2 weeks, 1 month, 3 months | — |
Countries
India
Contacts
Public ContactDrBhupesh Bagga
L V Prasad Eye Institute
Outcome results
None listed