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To compare the effect of carbon dioxide on blood supply of brain when using two anaesthesia agents in new born babies undergoing surgery and using ultrasound to look at the change in blood flow to the brain

Comparison of cerebro vascular reactivity to carbon dioxide at equi MAC doses of Isoflurane and sevoflurane in neonates (Varis study): A randomised controlled study - VARIS

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/085717
Enrollment
48
Registered
2025-04-28
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: P84- Other problems with newborn

Interventions

Intervention1: trans cranial colour coded duplex ultrasonography: ultrasound will be done at two points when end tidal CO2 is 35 mmHg and 45mmHg, at each end tidal value three readings will be taken a

Sponsors

Post Graduate Institute of Medical Education and Research, sector 12, Chandigarh
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Term neonates Scheduled for non Intrathoracic and non neurosurgical procedures under anaesthesia

Exclusion criteria

Exclusion criteria: Hemodynamically unstable and on inotropes Congenital heart disease Heart failure or respiratory disorders Preterm neonates

Design outcomes

Primary

MeasureTime frame
Change in mean flow velocity of the distal MCA (M1 segment) with the change in EtCO2 from 35mmHg to 45mmHgTimepoint: 15 minutes and 30 minutes

Secondary

MeasureTime frame
1. Change in systolic flow velocity of the distal MCA (M1 segment) with change in EtCO2 from 35 mmHg to 45 mmHg 2. Change in diastolic flow velocity of the distal MCA (M1 segment) with change in EtCO2 from 35 mmHg to 45 mmHg 3. Absolute CCO2R reactivity 4. Resistive index (RI) 5. Pulsatility index (PI) 6. Complications due to the procedure- pressure effects at temporal site, hemodynamic instability due to intervention (rescue therapy used- fluid bolus/vasopressor) Timepoint: 15 minutes, 30 minutes

Countries

India

Contacts

Public ContactDr Anudeep Jafra

Post Graduate Institute of Medical Education and Research

tjpreethy@gmail.com9417800203

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026