Which works better to reduce heart stress during intubation in patient undergoing surgery: Dexmedetomidine or Magnesium?

Comparison of intravenous magnesium sulphate versus dexmedetomidine in blunting of cardiovascular stress response following laryngoscopy and endotracheal intubation- A prospective randomised control study - NIL

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/085710

Enrollment

100

Registered

2025-04-28

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Magnesium Sulphate: Magnesium Sulphate dose of 30mg/kg given as infusion in 100ml normal saline intravenously over 10 minutes used for blunting of cardiovascular stress response during

Eligibility

Inclusion criteria

Inclusion criteria: 1. American society of anaesthesiologist class 1 & 2

Exclusion criteria

Exclusion criteria: 1.Pregnancy 2.Anticipated difficult airway 3.Unanticipated difficult airway requiring laryngoscopy time of more than 15 seconds 4.Obesity 5.Sinus bradycardia and any ECG abnormalities 6.Neuromuscular disorders 7.Allergic to study drug

Design outcomes

Primary

Measure	Time frame
To compare the changes in hemodynamic parameters following laryngoscopy and endotracheal intubation after administration of magnesium sulphate and dexmedetomidine Heart rate,systolic blood pressure, diastolic blood pressure, mean arterial pressure will be recorded at following time intervals Baseline 5,10, and 15 minutes since the start of drug infusion 30 seconds before laryngoscopy and intubation 1,3,5,10 after intubationTimepoint: In surgeries under general anesthesia using endotracheal tube	—

Measure

Time frame

To compare the changes in hemodynamic parameters following laryngoscopy and endotracheal intubation after administration of magnesium sulphate and dexmedetomidine Heart rate,systolic blood pressure, diastolic blood pressure, mean arterial pressure will be recorded at following time intervals Baseline 5,10, and 15 minutes since the start of drug infusion 30 seconds before laryngoscopy and intubation 1,3,5,10 after intubationTimepoint: In surgeries under general anesthesia using endotracheal tube

—

Secondary

Measure	Time frame
To assess the level of sedation using modified ramsay sedation score at 5,10,15 minutes since the start of drug infusion Timepoint: In surgeries under general anesthesia using endotracheal tube	—

Countries

India

Contacts

Public ContactDr Kauvya K

PSG Institute of Medical Science and Research

drprasanth1979@yahoo.co.in9344807280

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026