Health Condition 1: N979- Female infertility, unspecified
Conditions
Interventions
Intervention1: PRP: Peripheral blood (30 50 mL) is collected from the patient into tubes containing an anticoagulant (e.g., ACD) and centrifuged to separate plasma from red blood cells and the buffy c
Sponsors
Aruna R
Eligibility
Inclusion criteria
Inclusion criteria: A history of RIF (greater than or equal to 3 failed implantation attempts). A history of RPL (greater than or equal to 2 consecutive miscarriages). Diagnosed thin endometrium (less than 7 mm) in preparation for embryo transfer. Willingness to undergo PRP therapy. Signed informed consent. Endometrial Biopsy done and noted to not have Tuberculosis or Chronic Endometritis
Exclusion criteria
Exclusion criteria: Active infection or untreated pelvic inflammatory disease. Uterine abnormalities like fibroids or adhesions not amenable to treatment. Systemic conditions that contraindicate PRP therapy. Use of anticoagulant therapy or blood disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the effect of two methods of PRP preparation on endometrial thickness and vascularity in patients with thin endometrium and its subsequent impact on implantation and pregnancy rates. Timepoint: 6 weeks of pregnancy | — |
Secondary
| Measure | Time frame |
|---|---|
| Assess the role of PRP in improving pregnancy outcomes, measured as ongoing pregnancy rate ( OPR ) in patients with thin endometrium. Comparison of Platelet count, cytokines and growth factors in in-house activated PRP versus Tricell aPRP preparation Timepoint: 6 weeks of pregnancy | — |
Countries
India
Contacts
Public ContactDr Aruna R
Outcome results
None listed