FindTrial
Sign In

Comparison between intraoperative hemodynamic parameters and recovery profile with and without opioids in long duration cancer surgeries.

To compare the effects of opioid feee anesthesia (OFA) and opioid based anesthesia technique on perioperative parameters and recovery profile in patients undergoing long duration (more than 3 hours) onco-surgeries. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/085650
Enrollment
100
Registered
2025-04-25
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C01- Malignant neoplasm of base of tongue

Interventions

Intervention1: Dexmedetomidine: Anesthesia care with OFA regime using Dexmedetomidine at 1mcg/kg at the time induction
20 mins before the surgery starts, followed by infusion at the rate of 0.2mcg/kg/hr until the surgery continues. Control Intervention1: Fentanyl: Anesthesia care with opioid technique using fentanyl a

Sponsors

India educational trustdepartment of anesthesiaMahatma Gandhi medical college and hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA1;2;3 patients belonging to age group 18 to 70 years, all genders, who are mentally sound and communicable.

Exclusion criteria

Exclusion criteria: Patient refusal to participate in study. Allergy to study drugs. Patients with chronic cancer pain who have received opioids for pain management. Patients with chronic kidney or liver disease or AV conduction disorder or heart failure. Patients with unplanned mechanical ventilation in post operative period.

Design outcomes

Primary

MeasureTime frame
To compare hemodynamic stability and perioperative parameters (blood pressure, mean arterial pressure,ECG, Spo2, Heart rate) between opioid based anesthesia group and opioid free group.Timepoint: At the time of induction, followed by every 5mins until half an hour then every hour Intraoperatively until the end of surgery then post operative day 1,2 and 3.—

Secondary

MeasureTime frame
Comparison of post operative recovery profile between the two groups in terms of extubation, early mobilisation, length of stay in intensive care & length of stay in hospital. To compare the incidence & severity of peri operative complications between the two groups. To compare the total opioid consumption, total amount of analgesia drugs given in both the groups.Timepoint: At the time of induction, Intraoperative hourly, then post operative day 1,2,3 & on the day of discharge—

Countries

India

Contacts

Public ContactDr Shubham khandelwal

Mahatma Gandhi medical college and Hospital

Shubham.kh29@gmail.com9799052551

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026