Health Condition 1: H95-H95- Intraoperative and postprocedural complications and disorders of ear and mastoid process, not elsewhere classified
Conditions
Interventions
Intervention1: Drug intervention: Inj Metaclopramide 10mg IV is given post-operatively to treat severe nausea and vomiting
Control Intervention1: Inj Ondansetron 4mg IV + Inj Dexamethasone 8 mg IV vs
Sponsors
Hospital Shri Bhausaheb Hire Government Medical College DHULE
Eligibility
Inclusion criteria
Inclusion criteria: 1) Patients undergoing elective middle ear surgeries under general anaesthesia (with or without intubation) 2)Age 18-60 years 3)Male & Female 4) ASA physical status I,II
Exclusion criteria
Exclusion criteria: 1) Sensitivity to study drug 2) pregnant & lactating 3) History of use or addiction to other antiemetic drugs 4) cardiovascular/neurological/ history of psychiatric illness 5) history of motion sickness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) to compare effectiveness of Ondansetron - dexamethasone & Palonosetron - dexamethasone in preventing nausea & vomiting in first 24 hour post surgery 2) incidence of nausea & vomiting post operatively in study population 3) severity of nausea & vomiting post- operatively in study population 4) requirement of rescue anti emeticTimepoint: 0-2 hours , 2-6 hours , 6-24 hours post-operatively | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) identifying peak period of PONV , rapidity & duration of action of anti- emetic combination 2) To identify, compare & study side- effects of the drugs anyTimepoint: 24 hours post-operatively | — |
Countries
India
Contacts
Public ContactDr Hemanjali cherukuri
Shri Bhausaheb Hire Government Medical College, dhule
Outcome results
None listed