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A study to compare the effects of ondansetron, palanosetron and Amisulpride with dexamethasone to prevent nausea and vomiting postoperatively in patients undergoing laparoscopic cholecystectomy under general anaesthesia

A prospective study comparing the efficacy of amisulpride,palanosetron and ondansetron with dexamethasone for postoperative nausea and vomiting in patients coming for elective laparoscopic cholecystectomy under general anaesthesia-a randomised control trial - Nil

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/085584
Enrollment
120
Registered
2025-04-24
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group AD Group PD Group OD: Inj amisulpride 10mg + Inj dexamethasone 8mg intravenous Inj palanosetron 0.075mg + Inj dexamethasone 8mg intravenous Inj ondansetron 4mg + inj dexamethaso

Sponsors

RUTHRASREE K N
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I and ASA II patients , recently detected and controlled diabetes mellitus and hypertension

Exclusion criteria

Exclusion criteria: All ASA 3 and 4 Patients with known drug allergy, preexisting cardiovascular, respiratory ,neurological and renal disorders Uncontrolled diabetes and hypertension Patients with BMI more than 30kg/m2

Design outcomes

Primary

MeasureTime frame
To evaluate the incidence of nausea, retching and vomiting and incidence of total PONVTimepoint: 0hr 1hr 2hr 6hr 12hr 24hr—

Secondary

MeasureTime frame
To assess the incidence of headache,dizziness,diarrhoea,need of rescue antiemeticsTimepoint: 0hr 1hr 2hr 6hr 12hr 24hr—

Countries

India

Contacts

Public ContactDr Shashikala T K

Mysore medical college and research institute

drshi72@gmail.com9148650639

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026