Effect of different irrigant activation systems on biomarkers and postoperative pain levels in symptomatic irreversible pulpitis patients

Effect of different irrigant activation systems on GCF levels of NLRP3 and substance P and postoperative pain in patients with symptomatic irreversible pulpitis: A Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/085571

Enrollment

Registered

2025-04-24

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Ultrasonic Activation: Irrigant will be dispensed into the canal using a 31G single port side vented needle The final irrigant activation will be done using piezoelectric ultrasonic uni

Eligibility

Inclusion criteria

Inclusion criteria: 1. Male or female individuals aged 16 50 years. 2. Selected teeth - Single rooted mandibular Premolar diagnosed with symptomatic irreversible pulpitis. 3. Teeth with no canal curvature

Exclusion criteria

Exclusion criteria: 1. Patients who needed antibiotic prophylaxis in last 3 month 2. Patients with any systemic disease 3. Pregnant females during treatment 4. Patients with intense plaque or calculus on the teeth, redness and bleeding in the gingiva, severe gingivitis, generalized periodontitis, or more than a 3-mm gingival pocket depth will not be included in this study

Design outcomes

Primary

Measure	Time frame
Reduction in pain levelsTimepoint: 0hr, 6hr, 12h, 24h, 48h, 72h and 7th day	—

Secondary

Measure	Time frame
Reduction in inflammatory biomarkers levelTimepoint: 0hr and 7th day	—

Countries

India

Contacts

Public ContactDr Smita Singh

Manav rachna dental college

monikatandan.sds@mrei.ac.in9999063631

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026