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Comparing inflammatory biomarkers, salivary pH and oral health-related quality of life in patients wearing complete dentures fabricated with conventional and 3-D printed techniques

Comparative Evaluation of Interleukin-1 Beta, Salivary pH, and Oral Health-Related Quality of Life in Patients with Conventional Versus 3D Printed Complete Dentures : A Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/085517
Enrollment
32
Registered
2025-04-24
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: 3D-Printed Complete Denture : Evaluation of IL-1 beta in Patients with 3D-Printed Complete Denture at 3 time intervals: Pre Insertion, Post 1 week and 1 Month Post Insertion Evaluatio

Sponsors

Dr. Radhika Pujara
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Completely edentulous patients requiring maxillary and mandibular complete dentures. Patients aged 55 years and above. Patients with no salivary gland disorders or conditions/medications causing xerostomia. Patients classified as ACP Class I (Ideal or minimally compromised edentulous condition). Patients who is willing to participate in the study. Patients with no history of systemic conditions affecting salivary composition or inflammatory markers.

Exclusion criteria

Exclusion criteria: Patients with partial edentulism. Patients with salivary gland disorders or conditions/medications causing xerostomia. Patients with a history of autoimmune diseases, uncontrolled diabetes, or other systemic conditions affecting immune response. Patients who is not willing to participate in the study.

Design outcomes

Primary

MeasureTime frame
To evaluate and compare IL-1 beta in patients with conventional heat-cured and 3D-printed complete dentures: Before insertion, 1 Week Post Denture insertion and 4 Weeks Post Denture insertion To evaluate and compare salivary pH in patients with conventional heat-cured and 3D-printed complete denture at Before insertion, 1 Week Post Denture insertion and 4 Weeks Post Denture insertionTimepoint: Before Insertion, 1 Week Post Denture Insertion and 4 Weeks Post Denture Insertion—

Secondary

MeasureTime frame
To evaluate & compare the oral health-related quality of life (OHRQoL) of patients with conventional heat-cured & 3D-printed complete denturesTimepoint: Oral Health-Related Quality Of Life (OHRQoL) assessed at Before Denture Insertion & 4 Weeks Post Denture Insertion—

Countries

India

Contacts

Public ContactDr Radhika Pujara

Manav Rachna International Institute of Research and Studies

nehajain.sds@mrei.ac.in9818095343

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026