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Effect of a novel intracanal medicament on inflammatory marker levels and post endodontic pain in teeth with pulpal necrosis and symptomatic Apical Periodontitis.

Effect of a novel biguanide based intracanal medicament on substance p and mmp-9 levels and post endodontic pain in teeth with pulpal necrosis and symptomatic apical periodontitis. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/085508
Enrollment
42
Registered
2025-04-24
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: 0.2% PHMB gel: 0.2% polyhexamethylene biguanide gel will be used as intracanal medicament. frequency - once The intracanal medicament will be placed in the first visit for 1 week. Cont

Sponsors

Dr Prachi Mishra
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Mandibular single rooted teeth diagnosed with symptomatic apical periodontitis. 2. The preoperative pain score more than 54 on the Heft Parker Visual Analogue Pain Scale 3. Teeth with mature apices. 4. Healthy patients with age 18 and above.

Exclusion criteria

Exclusion criteria: 1. Patients with systemic disorders, patients taking steroids, pregnant patients. 2. Patients with a history of allergy to any of the components of local anesthesia, chlorhexidine, EDTA, or sodium hypochlorite. 3. Patients with a history of treatment with antibiotics within 1 month prior to the study. 4. Teeth with previous RCT. 5. Severely damaged or mutilated teeth. 6. Patients not willing to participate in the study and did not sign the consent form.

Design outcomes

Primary

MeasureTime frame
To evaluate and compare the impact of PHMB on post-endodontic pain in patients with pulpal necrosis and symptomatic apical periodontitis. Timepoint: 0hr, 6hr, 12hr, 24hr, 48hr, 72hr and 7th day—

Secondary

MeasureTime frame
To evaluate and compare the efficacy of PHMB with calcium hydroxide in influencing inflammatory markers and post-treatment pain. To investigate the correlation between the inflammatory mediator levels of Substance P and MMP 9 and the degree of pain relief experienced by patients. Timepoint: 0hr, 7th day—

Countries

India

Contacts

Public ContactDr Sonal Soi

Manav Rachna Dental Colllege

sonal.sds@mrei.ac.in8979266934

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026