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Comparision of rifaximin and lactulose in combination vs lactulose alone in prevention of constipation in critically ill chronic kidney disease patients

Comparative evaluation of rifaximin and lactulose in combination vs lactulose alone in prevention of constipation in critically ill chronic kidney disease patients; a randomized controlled trial. - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/085492
Enrollment
64
Registered
2025-04-24
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N17-N19- Acute kidney failure and chronic kidney disease

Interventions

Intervention1: Rifaximin and Lactulose: In addition to routine care , patients will recieve Tablet rifaximin 400mg thrice a day and Syrup lactulose 15ml at bedtime for 14 days Control Intervention1: L

Sponsors

All India Institute of Medical Sciences, Patna
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Critically ill severe chronic kidney disease patients (stage 4 and 5) 2.Patients expected to survive for more than 2 weeks

Exclusion criteria

Exclusion criteria: 1.Patients with multiorgan failure 2.Patients on multiple inotropes 3.Patients on sedatives like fentanyl,midazolam,etc

Design outcomes

Primary

MeasureTime frame
To measure the mean complete spontaneous bowel movements per week.Timepoint: 14 days—

Secondary

MeasureTime frame
To measure incidence , duration and severity of uremic encephalopathy between the two groupsTimepoint: 14 days;To measure severity of constipation using constipation scoring systemTimepoint: 14 days;To measure no of times dialysis and rectal enema required by the patients from both the groupsTimepoint: 14 days—

Countries

India

Contacts

Public ContactDr S V R Gandharv Kosireddi

All India Institute Of Medical Sciences , Patna

dramarjeetk@aiimspatna.org9570890646

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026