Health Condition 1: K859- Acute pancreatitis, unspecified
Conditions
Interventions
Intervention1: Oral pancreatic enzyme supplementation: pancreatic enzyme supplementation - 2 Tablets/ meal, each containing: Equivalent to Lipase 25000 USP units, Amylase 74700 USP units, Protease 625
Sponsors
The Indian Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: Acute pancreatitis with pancreatic necrosis within 28 days of pain, Able to take oral or enteral feed, pancreatic necrosis more than 30 percentage
Exclusion criteria
Exclusion criteria: Patients with Chronic Pancreatitis, Patients with more multi-organ failure at time of screening, Patient on ventilatory support, Pregnancy, Contraindication to enteral feeding or not tolerating enteral feed, Age lesser than 18 years or more than 75 years, Major comorbidity such as decompensated cirrhosis heart failure significant lung parenchymal or airway disease advanced chronic kidney disease, Previous pancreatic surgery, Known allergy to pancreatic enzyme supplementation components
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Days alive and out of hospital at 90 days. It will be counted as number of days the patient is not in hospital and alive. This parameter will take into account total duration of readmissions and mortality. DAOH90= Number of days alive (within 90 days of follow up) (Total hospitalization days at readmission).Timepoint: 90 days | — |
Secondary
| Measure | Time frame |
|---|---|
| a. All cause mortality b. Mean change in body weight from baseline in both groups c. Mean change in mid upper arm circumference at from baseline in both groups Timepoint: day 30, day 60 & day 90;Mean change in PAN PROMISE score as a measure of health related quality of life Timepoint: day 90 | — |
Countries
India
Contacts
Public ContactSudipta Dhar Chowdhury
Christian Medical College, Vellore
Outcome results
None listed