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Role of insulin eye drops in diseased corneas with reduced sensation

Role of Topical Insulin Therapy in Stage 2 Neurotrophic Keratopathy - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/085354
Enrollment
56
Registered
2025-04-23
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H168- Other keratitis

Interventions

Intervention1: Patients being treated with only topical insulin eyedrops: Patient with neurotrophic keratopathy will be started on Topical Insulin eyedrops They will be followed up after 1 week 1 mon

Sponsors

Sankara Eye Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Severe Dry Eye Disease Viral keratitis Chemical or mechanical trauma Chronic use of preserved Topical eyedrops Post- Ocular surgery or Neurosurgery Post irradiation Diabetes mellitus/ Keratopathy Recurrent Epithelial Erosions Neurological conditions like Vascular/ Space occupying lesions

Exclusion criteria

Exclusion criteria: Patients not willing for insulin therapy Pregnant & Nursing Mothers Active non-herpetic keratitis Post Keratoplasty Neurotrophic keratopathy One eyed patients

Design outcomes

Primary

MeasureTime frame
Complete re epithelialization of the Persistent Epithelial DefectTimepoint: Patient will be followed up after 1 week 1 month 2 months and 3 months respectively

Secondary

MeasureTime frame
1 Best-corrected visual acuity 2 Days until complete re-epithelialization 3 Any change in corneal sensation 4 Changes in Dry Eye Profile 5 Serial Slit Lamp Photo Evaluation 6 Changes in Epithelial Profile Impression Cytology using cellulose acetate filter paper Timepoint: Patient will be followed up after 1 week 1 month 2 months and 3 months respectively

Countries

India

Contacts

Public ContactDr Pallavi Joshi

Sankara Eye Hospital, Bengaluru, Karnataka

drpallavijoshi@gmail.com8147280162

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026