Changes at the micronuclear level in the mucosal cells around the implant with and without Melatonin gel.

Comparative evaluation of micro nuclear changes in mucosal epithelial cells, crestal bone levels and implant stability with and without melatonin gel- A randomized controlled clinical study. - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/085336

Enrollment

Registered

2025-04-22

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K069- Disorder of gingiva and edentulousalveolar ridge, unspecified

Interventions

Intervention1: Conventional implant placement + 2% melatonin gel: After the preparation of the osteotomy site with sequential drills, the implant is placed in the prepared site then the screw hole is

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients of age 20-60 year 2. Absence of restoration/ prosthesis adjacent to the edentulous site 3. Healthy extraction socket greater than or equal to 3 months. 4. Good oral hygiene.

Exclusion criteria

Exclusion criteria: 1. Patients with systemic diseases 2. Chronic smokers 3. Pregnant or lactating women 4. Patients with melatonin allergy.

Design outcomes

Primary

Measure	Time frame
Clinical parameters: Primary Implant stability Histological parameters: Micronuclear changes in the mucosal epithelial cells at the site of implant placement.Timepoint: Clinical parameters: Baseline and 3months Histological parameters: 3 months	—

Secondary

Measure	Time frame
Radiological parameters: Crestal bone levels by IOPATimepoint: Radiological parameters: Immediately after the implant placement and 3months after implant placement	—

Countries

India

Contacts

Public ContactDR JULIET JOSEPHIN J

Kamineni Institute of Dental Sciences

periomds@gmail.com9989183060

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026