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Role of magnesium sulphate and vitamin C in prevention of sore throat following endotracheal intubation

Efficacy of intraoperative magnesium sulphate and vitamin C in prevention of postoperative sore throat following endotracheal intubation - Nil

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/085238
Enrollment
90
Registered
2025-04-21
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H664- Suppurative otitis media, unspecified Health Condition 2: D34- Benign neoplasm of thyroid gland Health Condition 3: K87- Disorders of gallbladder, biliarytract and pancreas in diseases classified elsewhere Health Condition 4: S529- Unspecified fracture of forearm Health Condition 5: K469- Unspecified abdominal hernia without obstruction or gangrene Health Condition 6: T148- Other injury of unspecified body region

Interventions

Intervention1: Magnesium sulphate and vitamin C: 1gram of magnesium sulphate intravenous after induction of anaesthesia over 30 minutes and 2 grams of vitamin C intravenous after induction of anaesthe

Sponsors

Department of Anaesthesiology and Critical Care PGIMS Rohtak
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients in age group between 18 to 60 years of either sex, belonging to American Society of Anaesthesiologists (ASA) physical status I and II will be included in the study who will undergo general anaesthesia with placement of endotracheal tube.

Exclusion criteria

Exclusion criteria: Unwillingness of patient, history of preoperative sore throat,any recent use of anti-inflammatory drugs, major hepatic,renal, cardiovascular,respiratory and neuromuscular disease, duration of surgery more than 3 hours, attempts of endotracheal intubation more than one, pregnant and lactating women, previous history of allergy to study drug, anticipated difficult airway

Design outcomes

Primary

MeasureTime frame
Severity of postoperative sore throatTimepoint: At 0 h, 6 hours, 12 hours and 24 hours postoperatively

Secondary

MeasureTime frame
Side effects if anyTimepoint: At 0, 6 hours, 12 hours and 24 hours postoperatively

Countries

India

Contacts

Public ContactDr Priyanka Aggarwal

Pt BD Sharma University of Health Sciences Rohtak

aggarwal.priyanka93@gmail.com08607920759

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026