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Study to evaluate the use of ultrasound for assessing how much the breathing muscle called diaphragm thickens to help predict ventilation failure in a patient on tight fitting mask called noninvasive mask.

Evaluation of diaphragmatic thickening fraction for prediction of noninvasive ventilation failure A prospective, observational study - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/085216
Enrollment
115
Registered
2025-04-21
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J960- Acute respiratory failure

Interventions

Intervention1: Assessment of diaphragmatic thickness fraction using ultrasound for predicting NIV failure: Ultrasound assessment of diaphragmatic thickening fraction will be done within hour of NIV

Sponsors

Satya Kumar Moharana
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients age greater than 18 years 2.Patients presented to ICU with acute respiratory failure

Exclusion criteria

Exclusion criteria: 1.Patients requiring emergent endotracheal intubation upon ICU admission prior to recruitment. 2.Patients initiated on NIV in emergency department or ward prior to ICU admission 3.Patients with interstitial lung disease 4.Patients with neuromuscular disease 5.Patients with chest wall deformities 6.Pregnant female 7.NIV Intolerance Patient refusal for NIV because of NIV discomfort 8.Patients previously on NIV / Home BiPAP 9.Patients who have consented for Do not intubate / Do not resuscitate 10.Terminally ill patients 11.Patients electively intubated for a procedure.

Design outcomes

Primary

MeasureTime frame
1.To determine if diaphragmatic thickening fraction can be used to predict NIV failure in patients with acute respiratory failure.Timepoint: Assessment will be done till there is NIV success, NIV failure or after 48 hours of treatment with NIV, whichever comes earlier.—

Secondary

MeasureTime frame
1. To evaluate diaphragmatic thickening fraction and HACOR score vs HACOR score alone for the prediction of noninvasive ventilation failure in patients with acute respiratory failure. 2. To evaluate diaphragmatic thickening fraction vs HACOR score for the prediction of noninvasive ventilation failure in patients with acute respiratory failure.Timepoint: Assessment will be done till there is NIV success, NIV failure or after 48 hours of treatment with NIV, whichever comes earlier.—

Countries

India

Contacts

Public ContactDipali Anand Taggarsi

St Johns Medical College

dipali.tagg@gmail.com9902586487

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026