Health Condition 1: I958- Other hypotension
Conditions
Interventions
Intervention1: Push Dose Epinephrine: Patients in this arm will receive a prophylactic fixed bolus of Push-Dose Epinephrine (20 mcg) at T-2 minutes (approximately 2 minutes prior to the administration
no other aspects of the intubation procedure (e.g., choice of induction agent, pre-oxygenation method) are protocolized, reflecting real-world practice.
Sponsors
Department of emergency medicine AIIMS New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: All patients undergoing endotracheal intubation in the emergency department who are at risk of peri intubation cardiovascular collapse as defined by: Any patient with a shock index > 1.0 Any patient with a SBP 3. Any patient already on a continuous vasopressor infusion.
Exclusion criteria
Exclusion criteria: Age Pregnant patients HR > 140 bpm Patients in cardiac arrest SBP > 120 ( for patients on a CVI)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the incidence of peri-intubation cardiovascular collapse in patients undergoing endotracheal intubation in the emergency department receiving push dose epinephrine when compared to the existing care. Timepoint: 0 to 30 minutes with time 0 being the time of administration of inducing agents | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the early mortality at 7 days post intubation. Timepoint: 0 to 7 days minutes with time 0 being the time of administration of inducing agents during intubation;To assess the safety profile of push dose epinephrine - extreme tachycardia, severe hypertension, dysrhythmia & medication errors. Timepoint: 0 to 30 minutes post intubation;To compare the incidence of other peri intubation complications - severe hypoxia & cardiac arrest or death in the immediate post intubation period. Timepoint: 0 to 30 minutes post intubation. | — |
Countries
India
Contacts
Public ContactAkshay Kumar
AIIMS New Delhi
Outcome results
None listed