Health Condition 1: C01- Malignant neoplasm of base of tongue Health Condition 2: C04- Malignant neoplasm of floor of mouth Health Condition 3: C13- Malignant neoplasm of hypopharynx Health Condition 4: C00- Malignant neoplasm of lip Health Condition 5: C10- Malignant neoplasm of oropharynx Health Condition 6: C14- Malignant neoplasm of other and ill-defined sites in the lip, oral cavity and pharynx Health Condition 7: C02- Malignant neoplasm of other and unspecified parts of tongue Health Condi
Conditions
Interventions
Intervention1: Dose escalation using PETCT: To check the feasibility and tolerability of dose escalation using PETCT
Duration of intervention is 6 weeks
Control Intervention1: conventional chemo radi
Sponsors
Dr Naga Sireesha Kalla
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age 18-70 yrs 2.Biopsy-confirmed squamous cell carcinoma of the oropharynx, oral cavity, hypopharynx and larynx 3.Human Papilloma virus (HPV) negative status 4.Stage III/IVA/IVB, T3-4, N0-3, M0 5.Creatinine clearance greater than 60 ml 6.ECOG PS 0 to 1 7.No previous malignancies 8.Adequate bone marrow function, adequate hepatic function 9.Written informed consent 10.Able to comply with follow up
Exclusion criteria
Exclusion criteria: 1.Presence of distant metastases (AJCC stage IVC) 2.Previous radiotherapy in the head and neck region 3.Prior surgery, radiotherapy or chemotherapy for this tumor 4.Nasopharyngeal and para nasal sinus malignancies 5.HPV positive status 6.Patients who are not suitable for chemo-radiotherapy 7.Refusal of the patients to take part in the trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| feasibility and tolerability of dose escalation with PETCTTimepoint: During the course of treatment or intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| acute & late toxicities associated with dose escalationTimepoint: At baseline,6 weeks & 3 months | — |
Countries
India
Contacts
Public ContactDr Ajay Kumar Kondenti
AIIMS, Mangalagiri
Outcome results
None listed