Health Condition 1: C00-C14- Malignant neoplasms of lip, oral cavity and pharynx
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
All India Institute Of Medical Sciences, New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: a) Patients between age 18 and 70 years. b) Histologically proven squamous cell carcinoma of oral cavity. c) Patients with treatment na ve advanced oral cavity (T3-T4,N2a-N3b) squamous cell carcinoma. d) Patients amenable to primary treatment in the form of surgery.
Exclusion criteria
Exclusion criteria: ) Patients with prior history of any malignancy. b) Patients with history of receiving neoadjuvant/ induction therapy. c) Salvage surgery. d) Patients in whom tumor resection is not finally achieved because it shows intraoperatively that the tumor is locally advanced and unresectable. e) Patients with macroscopic residual tumor (R2)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To isolate and quantify Circulating tumor cells (CTCs) in patients with oral cavity squamous cell carcinoma 2. To investigate the kinetics of Circulating tumor cells (CTCs) with intraoperative tumor manipulation.Timepoint: 2 days | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) To study the relationship between circulating tumor cells and tumor microenvironment. 2) To study the subsite wise distribution of number of CTCs. 3) To study the correlation of CTC with the clinical attributes (TNM stage, subsite, skin involvement, masticator space). 4) Planned subset analysis Difference in CTC kinetics in cohorts with Internal jugular vein ligation v/s preservation.Timepoint: 6 weeks | — |
Countries
India
Contacts
Public ContactROHAN GUPTA
All India Institute Of Medical Sciences, New Delhi
Outcome results
None listed