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A double-blind, randomized, placebo-controlled study to test the effect of painkiller acetaminophen in affective planning, learning and metacognitive behavior of healthy human volunteers.

Role of Acetaminophen in Affective and Social Decision making - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/085107
Enrollment
300
Registered
2025-04-17
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Acetaminophen: 1000 mg, orally only once (before one time experimental session lasting 1-2 hrs) Control Intervention1: Placebo: 1000 mg, orally only once (before one time experimental s

Sponsors

K M Sharika
Lead Sponsor
Himanshu Sharma
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Healthy volunteers as advised by enrolling doctor following basic health screening

Exclusion criteria

Exclusion criteria: someone who 1) has taken any drug/medication/alcohol in the last 72 hours or 2) has an acute/chronic, medical/surgical condition that can affect the study outcome (as advised by enrolling doctor) will be excluded from participating in the study

Design outcomes

Primary

MeasureTime frame
Behavioral indices of concurrent movement planning, decision confidence (metacognition) and biases in reward based learning, if any, in different experiments.Timepoint: One time assessment after approx 1 hour after oral administration of the drug/ placebo

Secondary

MeasureTime frame
Neural indices of concurrent movement planning, decision confidence (metacognition) & biases in reward based learning, if any, in different experiments.Timepoint: One time assessment after approx 1 hour after oral administration of the drug/ placebo

Countries

India

Contacts

Public ContactK M SHARIKA

Indian Institute of Technology (IIT) Kanpur

sharika@iitk.ac.in5122594772

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026