Comparative Evaluation Of The Effect Of Antioxidant Therapy On Oxidative Stress Produced In Patients Undergoing Fixed Appliance Therapy-A Randomized Controlled Trial

Comparative Evaluation Of The Effect Of Antioxidant Therapy On Oxidative Stress Produced In Patients Undergoing Fixed Appliance Therapy-A Randomized Control Trial - Nil

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/084903

Enrollment

Registered

2025-04-16

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Patients undergoing fixed orthodontic treatment and taking antioxidant supplements: patients receiving fixed orthodontic treatment with Antoxid HC capsule orally once daily for 3 months

Eligibility

Inclusion criteria

Inclusion criteria: - Patients with good general and oral health - Patients with no prior orthodontic treatment in last 24 months

Exclusion criteria

Exclusion criteria: - Smokers or tobacco users - Patients with active periodontal disease at the time of enrollment - Patients with systemic diseases such as diabetes, autoimmune diseases, or chronic inflammatory conditions. - Patients taking antioxidant supplements, multivitamins, or medications that could affect oxidative stress levels within the past 6 weeks. - Patients undergoing concurrent dental treatments that may influence salivary biomarkers (e.g., periodontal therapy, restorative treatments).

Design outcomes

Primary

Measure	Time frame
To evaluate and compare the impact of antioxidant supplements on oxidative stress levels in patients undergoing fixed orthodontic therapy, using salivary biomarkersTimepoint: T1: Before starting the fixed orthodontic therapy. T2: One-month follow-up. T3: Three-month follow-up.	—

Secondary

Measure	Time frame
To determine the temporal changes in oxidative stress levels (at baseline, 1 month, and 3 months) in patients undergoing fixed orthodontic therapyTimepoint: T1: Before starting the fixed orthodontic therapy. T2: One-month follow-up. T3: Three-month follow-up. ;1. To assess the oxidative stress generated in patients undergoing fixed orthodontic treatment.Timepoint: T1: Before starting the fixed orthodontic therapy. T2: One-month follow-up. T3: Three-month follow-up. ;3. To compare the levels of oxidative stress in patients receiving fixed orthodontic therapy with and without antioxidant supplementation.Timepoint: T1: Before starting the fixed orthodontic therapy. T2: One-month follow-up. T3: Three-month follow-up.	—

Measure

Time frame

To determine the temporal changes in oxidative stress levels (at baseline, 1 month, and 3 months) in patients undergoing fixed orthodontic therapyTimepoint: T1: Before starting the fixed orthodontic therapy. T2: One-month follow-up. T3: Three-month follow-up. ;1. To assess the oxidative stress generated in patients undergoing fixed orthodontic treatment.Timepoint: T1: Before starting the fixed orthodontic therapy. T2: One-month follow-up. T3: Three-month follow-up. ;3. To compare the levels of oxidative stress in patients receiving fixed orthodontic therapy with and without antioxidant supplementation.Timepoint: T1: Before starting the fixed orthodontic therapy. T2: One-month follow-up. T3: Three-month follow-up.

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Countries

India

Contacts

Public ContactDr Asavari Desai

Manipal College of Dental Sciences, Mangalore

desaiasavari@gmail.com9483363045

Outcome results