Comparing the Effects of Different Natural Biotic Irrigants on Infection and Inflammation in Childrens Teeth.

Comparative Evaluation of the Antimicrobial Efficacy and Periradicular Inflammatory Biomarkers of Prebiotic, Probiotic, Synbiotic and Postbiotic Irrigants in Primary Molars A Randomized Controlled Trial. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/084899

Enrollment

Registered

2025-04-16

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Prebiotic Irrigant: Prebiotic Irrigant prepared using Allium Sativum Extract diluted in distilled water will be used during during biomechanical preparation of the canal 5 times for 30

Eligibility

Inclusion criteria

Inclusion criteria: a)Normal, Healthy Children between 4 to 9 years b)Primary molars with irreversible pulpitis c)Primary molars roots should exhibit minimal or no resorption. d)IOPA Radiograph examination revealing primary molars with two thirds of each root remaining.

Exclusion criteria

Exclusion criteria: a)Primary molars with perforated pulpal floor and sinus tract. b)Primary molars with intraoral & extraoral swelling. c)Primary molars with Grade III, IV mobility. d)Children with special healthcare needs and systemic disorders.

Design outcomes

Primary

Measure	Time frame
1. To evaluate the antimicrobial efficacy of different irrigants - prebiotic, Probiotic, Synbiotic and Postbiotic Irrigants in primary molars during pulpectomy. 2. To assess changes in the levels Periradicular inflammatory biomarkers (IL-8, IL-10) before irrigation and 72 hours after irrigation with different irrigants. Timepoint: 1. Microbial load evaluated pre and post irrigation 2. levels of Periradicular inflammatory biomarkers to be evaluated pre and post 72 hours of irrigation	—

Measure

Time frame

1. To evaluate the antimicrobial efficacy of different irrigants - prebiotic, Probiotic, Synbiotic and Postbiotic Irrigants in primary molars during pulpectomy. 2. To assess changes in the levels Periradicular inflammatory biomarkers (IL-8, IL-10) before irrigation and 72 hours after irrigation with different irrigants. Timepoint: 1. Microbial load evaluated pre and post irrigation 2. levels of Periradicular inflammatory biomarkers to be evaluated pre and post 72 hours of irrigation

—

Secondary

Measure	Time frame
To develop a novel biologically derived irrigant for better treatment outcome for pediatric patient.Timepoint: Pre and Post Irrigation	—

Countries

India

Contacts

Public ContactDr Tanu Nangia

Manav Rachna Dental College

tanunangia.sds@mrei.ac.in9999384333

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026