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A Study to Compare the Effects of Two Medicines, Remifentanil and Fentanyl, on Heart Rate, Blood Pressure and other vital parameters during Tube Insertion in participating patients undergoing planned Surgery Under General Anesthesia.

Comparison of Effects of Remifentanil and Fentanyl on Hemodynamic Response to Endotracheal Intubation in Patients undergoing Elective Surgeries under General Anesthesia A Prospective Randomised Control Double Blinded Study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/084898
Enrollment
64
Registered
2025-04-16
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: DRUGS COMPARED- FENTANYL AND REMIFENTANIL: PATIENT TO RECEIVE EITHER OF THE DRUGS AS PER DOUBLE BLIND STUDY AND RANDOMISATION. IT INVOLVES COMPARATIVE STUDY OF BOTH THE DRUG IN PREVENTI

Sponsors

PD Hinduja Hospital and Medical Research Centre
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA Grade I AND II patients undergoing surgeries under General Anaesthesia at P D Hinduja Hospital and Medical Research Centre.

Exclusion criteria

Exclusion criteria: Patient Refusal Anticipated Difficult Intubation Obese patients with BMI more than 30kg/m2 Emergency Surgery History of Allergy to study drugs Pregnancy

Design outcomes

Primary

MeasureTime frame
To compare the efficacy of a bolus dose of Remifentanil 1 mcg/kg over 1 minute followed by infusion at 0.1 mcg/kg/min vs. a bolus dose of Fentanyl 1 mcg/kg over 1 minute in blunting the hemodynamic response to endotracheal intubation in patients undergoing elective surgery under general anesthesia, by measuring Heart Rate (HR), Systolic (SBP), Diastolic (DBP), Mean Arterial Pressure (MAP), and Rate Pressure Product (RPP), and assessing outcomes at 1 min post-intubation.Timepoint: Heart Rate (HR), Systolic (SBP), Diastolic (DBP), Mean Arterial Pressure (MAP), and Rate Pressure Product (RPP) recorded at baseline (pre-induction), at 1, 2, and 3 minutes post-induction with Propofol 2 mg/kg (titrated to loss of verbal response) and Vecuronium 0.1 mg/kg, then at 1, 3, and 5 minutes post-intubation. Outcome assessment to be compared at 1 minute, the peak of intubation response.—

Secondary

MeasureTime frame
Comparison of Dose of IV Propofol Required as Induction Agent in Patients Under Elective Surgeries Under General Anesthesia in Both the Groups.Timepoint: The requirement of Propofol will be considered till 3 minute after induction of General Anaesthesia—

Countries

India

Contacts

Public ContactDr Sunita Nandkumar

P D Hinduja Hospital and Medical Research Center

kotharimadhuri4@gmail.com9969279134

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026