Health Condition 1: K80-K87- Disorders of gallbladder, biliary tract and pancreas
Conditions
Interventions
Control Intervention1: Cap Duloxetine 60 mg: 60 mg of capsule Duloxetine orally one hour prior to the surgery for VAS assessment for 24 hrs
Control Intervention2: Cap Pregabalin 75 mg: 75 mg of capsul
Sponsors
Dayanand medical college and hospital Ludhiana Punjab
Eligibility
Inclusion criteria
Inclusion criteria: 1. ASA grade I-III patients 2. Adult patients (18-65 years) 3. Either gender 4. Patients scheduled for laparoscopic cholecystectomy under general anaesthesia.
Exclusion criteria
Exclusion criteria: 1. Patient with known allergy to any of the study drug 2. ASA grade IV or more 3. Patients with underlying psychiatric disorders 4. Patients on antiepileptics or MAO inhibitors 5. Patients on chronic pain medications 6. Patients with H/O SIADH • Patients with H/O syncope • Lactating and pregnant females • Patient refusal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the analgesic efficacy of oral Pregabalin and Duloxetine using VAS scoreTimepoint: VAS score at PACU at 0 minutes (on shifting to PACU), 1, 2, 4, 8, 12, 24 hours postoperatively | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To compare the consumption of total rescue analgesic in first 24 hours postoperatively 2. Postoperative sedation using five point NSS scale 3. The frequency of postoperative nausea & vomiting using four point PONV ScaleTimepoint: Postoperative sedation & postoperative nausea & vomiting at 0 min(on shifting to PACU) 1, 2,4,8,12,24 hours.Time to first rescue analgesia & total amount of rescue analgesia required in first 24 hours postoperatively | — |
Countries
India
Contacts
Public ContactDr Manpreet Kaur
Dayanand medical college and hospital Ludhiana Punjab
Outcome results
None listed