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Relation of genetic factors with Retinopathy of prematurity

Co-relation of VEGF 460 T/C and VEGF 634 G/C single nucleotide polymorphism with retinopathy of prematurity - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/04/084885
Enrollment
100
Registered
2025-04-16
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H351- Retinopathy of prematurity

Interventions

Intervention1: NIL: As it is an observational study Control Intervention1: NIL: As it is an observational study

Sponsors

Dr Neha K Sethi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Preterm babies with Gestational age less than 34 weeks, Birth weight less than 2000 grams, GA 34to36 weeks with RDS, NEC, sepsis and other high risk features according to RBSK guidelines 2. Those who develop ROP will be enrolled as cases and those who do not develop ROP with complete retinal vascularisation will be enrolled as controls.

Exclusion criteria

Exclusion criteria: 1. Babies not completing follow-up i.e. completion of retinal vascularisation due to any reason. 2. Babies with congenital ocular malformations impeding view of retina and ROP screening will also be excluded.

Design outcomes

Primary

MeasureTime frame
Odd s ratio of ROP occurrence with single nucleotide polymorphisms on VEGF 460 and VEGF 634 lociTimepoint: study will be completed in approximately 2 years.—

Secondary

MeasureTime frame
NATimepoint: NA—

Countries

India

Contacts

Public ContactNeha K Sethi

Guru Gobind Singh Medical College and Hospital, Faridkot

neha.knew@gmail.com9888129095

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026