A clinical trial on nellimulliyathi kashayam in the management of raththa kothippu noi(systemic hypertension)

A prospective open labelled, single arm, non-randomized, single centric, phaseII clinical trial to determine the effectiveness of nellimulliyathi kashayam in the management of raththa kothippu noi(systemic hypertension) - NK

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/084883

Enrollment

Registered

2025-04-16

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I10- Essential (primary) hypertension

Interventions

Intervention1: NELLIMULLIYATHI KASHAYAM: DOSAGE: 30-60ml twice a day for 50 days Control Intervention1: NIL: Nil

Eligibility

Inclusion criteria

Inclusion criteria: 1. Known Systemic Hypertension 2. High Normal SBP 130-139 mmHg and/or DBP 85-89 mmHg 3. Grade 1 Hypertension SBPÂ 140-159 mmHg and/or DBP 90-99 mmHg. 4. Grade 2 Hypertension SBP 160-179 mmHg and/or DBP 100-109 mmHg

Exclusion criteria

Exclusion criteria: 1. Known Malignant hypertension 2. Ischemic heart diseases 3. Chronic kidney disease 4. Chronic liver disease 5. Malignancy 6. Hyperlipidemia 7. Diabetes mellitus 8. Smoking and Alcohol

Design outcomes

Primary

Measure	Time frame
The outcome will be aimed to reduce SBP less than or equal to 130mmHg and DBP less than or equal to 90mmHg and to determine the therapeutic efficacy of clinical trial drug ( Nellimulliyathi Kashayam)Timepoint: 50 Days	—

Secondary

Measure	Time frame
1. To collect various Siddha literatures and modern journals for literature review on RATHTHA KOTHIPPU NOI. 2. To study other cofactors related to disease like age, sex, dietary habits, family history, and socioeconomic status. 3. To perform physicochemical, phytochemical, bio chemical analysis of NELLIMULLIYATHI KASHAYAM. 4. To evaluate pharmacological activities of NELLIMULLIYATHI KASHAYAM. 5. To perform molecular docking studies on the trial drug in ACE inhibitor and Angiotensin receptor blocker activities. 6. To study about the prevalence of RATHTHA KOTHIPPU NOI in relation with diet and lifestyle. 7. To evaluate Siddha parameters (including Envagai thervu, Neerkuri-Neikuri,Uyir Thaathu,Udal Thathu) in RATHTHA KOTHIPPU NOI during trial period. 8. To evaluate modern parametric changes in RATHTHA KOTHIPPU NOI.Timepoint: 6 months	—

Measure

Time frame

1. To collect various Siddha literatures and modern journals for literature review on RATHTHA KOTHIPPU NOI. 2. To study other cofactors related to disease like age, sex, dietary habits, family history, and socioeconomic status. 3. To perform physicochemical, phytochemical, bio chemical analysis of NELLIMULLIYATHI KASHAYAM. 4. To evaluate pharmacological activities of NELLIMULLIYATHI KASHAYAM. 5. To perform molecular docking studies on the trial drug in ACE inhibitor and Angiotensin receptor blocker activities. 6. To study about the prevalence of RATHTHA KOTHIPPU NOI in relation with diet and lifestyle. 7. To evaluate Siddha parameters (including Envagai thervu, Neerkuri-Neikuri,Uyir Thaathu,Udal Thathu) in RATHTHA KOTHIPPU NOI during trial period. 8. To evaluate modern parametric changes in RATHTHA KOTHIPPU NOI.Timepoint: 6 months

—

Countries

India

Contacts

Public ContactProf Dr T Komalavalli Alais Megala

Government Siddha Medical College and Hospital

justusantony71@gmail.com9443090849

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026