Health Condition 1: G20- Parkinsons disease
Conditions
Interventions
Intervention1: Strength training: The intervention will be a total of 12 weeks long, where participants will be trained by an experienced physiotherapist on the date of screening and on Day2. The trai
Sponsors
Indian Council of Medical Research(ICMR)
Eligibility
Inclusion criteria
Inclusion criteria: Individuals diagnosed with Idiopathic Parkinsons disease according to MDS clinical diagnostic criteria. Patients of either sex between the age of 40 to 75 years and Hoehn and Yahr stages 1 to 3 who can stand unassisted for two minutes and having a clinically apparent gait problem will be included in the study. Patients will require access to smartphone for AV recording and viewing the training program. Patient must have a study partner who will assist him/ her in the domiciliary training sessions.
Exclusion criteria
Exclusion criteria: PD patients with dyskinesia will not be enrolled. Patients with significant musculoskeletal problems or chronic pain, which might be aggravated by training or interfere with the outcome as perceived by the PI/ Co-I, will be excluded. Patients with a neurological disease other than PD or other physical impairments that would prevent participation in the muscular strength testing will be excluded on screening. PD patients with uncontrolled systemic diseases (e.g. hypertension, heart diseases, etc.) or significant cognitive impairment or refractory psychiatric symptoms will also be excluded, as will those who are already participating in a structured exercise program (including yoga, regular supervised/unsupervised stretching, or aerobic training). However, those who walk for their fitness regularly, may be included in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of changes in muscle strength, motor function and cognition between standard treatment versus add-on strength training (ST) for evaluation of efficacy of ST.Timepoint: Day 0, week 4, week 8, week 12 (for all) and week 24 (for active intervention group) | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of changes in electrophysiological biomarkers between standard treatment versus add-on strength training (ST) to understand the mechanism of strength training.Timepoint: Day 0, week 4, week 8, week 12 (for all) and week 24 (for active intervention group);Comparison of reported adverse event frequency and other safety parameters between standard treatment versus add-on strength training (ST) for evaluation of safety of ST.Timepoint: Day 0, week 4, week 8, week 12 (for all) and week 24 (for active intervention group);Comparison of changes in molecular biomarkers between standard treatment versus add-on strength training (ST) to understand the mechanism of strength training.Timepoint: Day 0, week 12 (for all) and week 24 (for active intervention group) | — |
Countries
India
Contacts
Public ContactDr Supriyo Choudhury
Institute of Neurosciences Kolkata
Outcome results
None listed