Health Condition 1: F102- Alcohol dependence
Conditions
Interventions
Intervention1: NIL: NIL
Control Intervention1: NIL: NIL
Sponsors
Kasturba Hospital
Eligibility
Inclusion criteria
Inclusion criteria: For AD - Individual diagnosed with alcohol dependence by a qualified psychiatrist at the Department of Psychiatry, Kasturba Medical College, MAHE Manipal Capable of providing informed consent Willing to participate in blood sampling For Healthy - Individual with no history of alcohol dependence and other substance use. Not having any first-degree relatives with a history of a major psychiatric disorder No psychiatric disorder screened using the Self Reporting Questionnaire SRQ Age and sex-matched to the alcohol-dependent group Capable of providing informed consent Willing to participate in blood sampling
Exclusion criteria
Exclusion criteria: For AD - Individuals currently diagnosed with major chronic or terminal diseases such as cardiovascular diseases and cancers major infectious conditions and severe mental disorders as well as lactating mothers and pregnant women Because these conditions can potentially influence DNA methylation patterns Individual having substance dependence other than alcohol and tobacco For Healthy - Individuals having first-degree relatives with a history of a major psychiatric disorder Individuals currently diagnosed with major chronic or terminal diseases such as cardiovascular diseases and cancers major infectious conditions and severe mental disorders as well as lactating mothers and pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hypo or hypermethylation of the candidate gene assessed using methylation specific PCR and their impact on gene expressionTimepoint: Baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Identification of dysregulated pathways & comorbidities associated with alcohol dependenceTimepoint: Baseline | — |
Countries
India
Contacts
Public ContactDr Vinod C Nayak
Kasturba Medical College Manipal Academy of Higher Education Manipal
Outcome results
None listed