Health Condition 1: B150- Hepatitis A with hepatic coma Health Condition 2: B162- Acute hepatitis B without delta-agent with hepatic coma Health Condition 3: B159- Hepatitis A without hepatic coma Health Condition 4: B169- Acute hepatitis B without delta-agent and without hepatic coma Health Condition 5: B178- Other specified acute viral hepatitis Health Condition 6: B179- Acute viral hepatitis, unspecified Health Condition 7: D899- Disorder involving the immune mechanism, unspecified Health Con
Conditions
Interventions
Intervention1: Low Volume Plasma Exchange in patients with Acute Liver Failure: Low Volume Plasma Exchange in patients with Acute Liver Failure - Patients allocated randomly in this arm. Total 21 case
Sponsors
Post Graduate Institute of Medical Education and Research Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: Diagnosed with acute liver failure as per EASL/INASL/AASLD criteria. No evidence of active infection. Willing to give informed consent. Those who are not enrolled in any other study. Patients who are not intended for liver transplantation.
Exclusion criteria
Exclusion criteria: Pregnancy. Microbiological or radiological evidence of infection. Known allergy to plasma, Protamine or Heparin. Severe systemic illness like HIV. Active hemorrhage. Liver, Kidney or any other transplant recipients will be excluded. Severe pre existing cardiopulmonary disease. Coexisting HCC or any other malignancy. Death within 24 hours of presentation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess efficacy of plasma exchange in terms of mortality on day 30.Timepoint: To assess efficacy of plasma exchange in terms of mortality on day 30. | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement in ALFED score, SOFA score, Clinical Prognostic index, KCH criteria to be assessed on pre procedure and on day 1,3,5,7 post procedure. Hematological and biochemical parameters will be assessed.Timepoint: On day 0(pre procedure), post procedure day 1,3,5,7 | — |
Countries
India
Contacts
Public ContactDr Divjot Singh Lamba
Post Graduate Institute of Medical Education and Research
Outcome results
None listed