Effect of pre-surgery carbohydrate drink on body temperature and stress response in patients undergoing oral cancer surgery

Evaluating the Role of Preoperative Carbohydrate Loading in Perioperative Outcomes in Oral Cancer Patients: A Open Label Randomised Control Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/084770

Enrollment

Registered

2025-04-15

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C069- Malignant neoplasm of mouth, unspecified

Interventions

Intervention1: CARBOHYDRATE LOADING: Patients receive pre op carbohydrate loading 800 ml of clear fluid of 12.5% maltodextrin on evening before surgery and 400ml of clear fluid 2hrs before surgery Con

Eligibility

Inclusion criteria

Inclusion criteria: All patients aged 18 years to 65years (American society of anaesthesiologist grading I, II, III) to be taken for Oral cancers.

Exclusion criteria

Exclusion criteria: 1. Patients refused to participate in the study 2. Patients with score >3 (NRS 2002) 3. BMI or equal to 30 kg/m2 4. Recurrent oral cancer, metastasis 5. Patients with preoperative radiotherapy or chemotherapy, diabetes mellitus, haematological disease, psychiatric illness, systemic inflammation, immune-modulatory therapy, those with increased risk of gastric aspiration. 6. Patients in whom perioperative albumin supplementation is expected 7. Patients who have had blood transfusion in last 15 days 8. Patient with nil mouth opening 9. Patients with deranged LFT

Design outcomes

Primary

Measure	Time frame
To investigate the effect of preoperative carbohydrate loading on perioperative catabolic stress response which will be assessed by delta change in albumin levels (preop Day 2) in patients undergoing surgery for oral cancers.Timepoint: BASELINE, 24HRS, 48HRS	—

Secondary

Measure	Time frame
1. To assess effect of carbohydrate loading on biomarkers (albumin, IL6, NLR, CRP) of stress response on Day 1 & Day 3 2. To determine the lowest temperature attained by patient during the perioperative period. 3. To assess blood sugars in both the groups at regular intervals till 24 hrs post-surgery 4. To compare weight loss at Day 7 in both the groups 5. Length of stay, post operative complications 6. Comparison of Glasgow prognostic index in both the groups 7. 30-day mortality with Clavin-Dindo score Timepoint: BASELINE 3OMINS INTRAOP 24HRS 48HRS 72HRS DAY7 DAY 30	—

Measure

Time frame

1. To assess effect of carbohydrate loading on biomarkers (albumin, IL6, NLR, CRP) of stress response on Day 1 & Day 3 2. To determine the lowest temperature attained by patient during the perioperative period. 3. To assess blood sugars in both the groups at regular intervals till 24 hrs post-surgery 4. To compare weight loss at Day 7 in both the groups 5. Length of stay, post operative complications 6. Comparison of Glasgow prognostic index in both the groups 7. 30-day mortality with Clavin-Dindo score Timepoint: BASELINE 3OMINS INTRAOP 24HRS 48HRS 72HRS DAY7 DAY 30

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Countries

India

Contacts

Public ContactDr Priyanka Sethi

All India Institute of Medical Sciences, Jodhpur

dr.priyanka_sethi@yahoo.co.in9352206300

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026