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Genetic Analysis of Severe Short stature Children and Adolescents and Predicting response to Growth hormone treatment

Molecular Genetic Analysis of Severe Short stature Children and Adolescents and Predictors of response to Growth hormone therapy - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/04/084748
Enrollment
80
Registered
2025-04-15
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E343- Short stature due to endocrine disorder

Interventions

Intervention1: NIL: NIL

Sponsors

Government Rajaji hospital and Madurai Medical college
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All the Children and Adolescents of 1 to 18 years with Severe short stature (height SDS less than -3SDS) of mean height for their specific age and sex.

Exclusion criteria

Exclusion criteria: Disproportionate short stature. Skeletal dysplasia, kyphoscoliosis & other skeletal deformities. Chronic systemic illness(CKD). Short stature due to nutritional/environmental/perinatal causes. Constitutional delay in growth and puberty.

Design outcomes

Primary

MeasureTime frame
To identify the genetic variants of severe short stature children and adolescents by whole exome sequencing. To assess the various predictors of growth hormone therapy response.Timepoint: To identify the genetic variants of severe short stature children and adolescents by whole exome sequencing. To assess the various predictors of growth hormone therapy response at 3 months, 6 months,1 year.—

Secondary

MeasureTime frame
To assess the genotype phenotype correlation. To determine the children at risk for evolving other Pituitary hormone deficiencies. To elicit the novel mutations.Timepoint: 2 years—

Countries

India

Contacts

Public ContactDr Sridhar S

Madurai Medical college

drsridharjipmer@gmail.com9789720246

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026