A study to determine the lowest weight based dose of Phenylephrine to prevent hypotension in patients undergoing Lower Segment Cesarean Section under Spinal Anesthesia

Evaluation of varying weight based doses of continuous phenylephrine infusion for prevention of hypotension in patients undergoing cesarean section under spinal anesthesia-A Prospective Randomised Double Blinded Study. - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/084743

Enrollment

192

Registered

2025-04-15

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium

Interventions

Intervention1: Phenylephrine infusion.: Phenylephrine infusion at one of the dosages- 0.1mcg/kg/min, 0.2mcg/kg/min, 0.3mcg/kg/min started after spinal anesthesia and continued till uterine closure Con

Eligibility

Inclusion criteria

Inclusion criteria: 1.Parturient with singleton pregnancy for elective Lower Segment Cesarean Section 2.Age more than 18years 3.ASA II

Exclusion criteria

Exclusion criteria: 1.hypertensive disorders of pregnancy 2 BMI more than 35kg/m2 3. Gestational age less than 36weeks 4.Antepartum hemorrhage 5. Any contraindications for Spinal Anesthesia

Design outcomes

Primary

Measure	Time frame
Incidence of hypotensionTimepoint: Incidence of hypotension is assessed 1min after giving spinal Anesthesia until delivery of the baby.	—

Secondary

Measure	Time frame
1.To determine ED50 and ED90 dose for phenylephrine 2.Incidence of Shivering 3.Intraoperative Temperature between groups 4.Adverse effects -Bradycardia, HypertensionTimepoint: 1.ED50 and ED90 of phenylephrine dose that prevents hypotension 2.Patient is assessed for incidence of shivering throughout the surgery and till discharge from PACU 3.Temperature is monitored every 15mins from start of spinal anesthesia till the end of surgery 4.any incidence of bradycardia or hypertension in the intraoperative period	—

Measure

Time frame

1.To determine ED50 and ED90 dose for phenylephrine 2.Incidence of Shivering 3.Intraoperative Temperature between groups 4.Adverse effects -Bradycardia, HypertensionTimepoint: 1.ED50 and ED90 of phenylephrine dose that prevents hypotension 2.Patient is assessed for incidence of shivering throughout the surgery and till discharge from PACU 3.Temperature is monitored every 15mins from start of spinal anesthesia till the end of surgery 4.any incidence of bradycardia or hypertension in the intraoperative period

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Countries

India

Contacts

Public ContactDr Akilandeswari M

Sri Ramachandra institue of higher education

akilaanes@gmail.com9840636238

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026