interventional study comparing the outcome of administering combined intraarticular and intraosseous Platelet Rich Plasma for one set of participants against intraarticular Platelet Rich Plasma injection alone in another set of participants in early knee osteoarthritis

Evaluating combined intraarticular and intraosseous PRP Vs intraarticular PRP injection in early knee osteoarthritis. - nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/084739

Enrollment

Registered

2025-04-15

Start date

Unknown

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M170- Bilateral primary osteoarthritis of knee

Interventions

Intervention1: Combined intra-articular and intraosseous PRP in early knee osteoarthritis: PRP will be injected both intraarticularly (8ml for one knee joint) and in intraosseous route (5ml in tibial

Eligibility

Inclusion criteria

Inclusion criteria: Patients from age of 35 to 70

Exclusion criteria

Exclusion criteria: Secondary osteoarthritis. Immunocompromised status or uncontrolled diabetes. Symptomatic OA affecting joints other than the knee. Recent intra-articular steroid or hyaluronic acid injections in the knee joint. Anticoagulation therapy. Active or previous infections.

Design outcomes

Primary

Measure	Time frame
Assessment of improvements in clinical VAS score, radiological parameters, and functional outcomes using WOMAC and KOOS scoresTimepoint: 6 months	—

Secondary

Measure	Time frame
To look for any adverse effects due to combined intra-osseous and intra-articular PRP injection in early OA knee (fever, pain, allergic reactions etc).Timepoint: 6 months	—

Countries

India

Contacts

Public ContactDr Ankit Dadra

Post graduate Institute of Medical Education and Research

ankitdadra@gmail.com9888648830

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 29, 2026