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Comparison of Adaptive support ventilation and PSIMV modes of ventilation in terms of duration of mechanical ventilation: A RCT

Adaptive support ventilation versus Pressure-Controlled Synchronized Intermittent Mandatory Ventilation in Critically ill children: An open label randomized controlled trial - SIMV-A TRIAL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/084738
Enrollment
140
Registered
2025-04-15
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J22- Unspecified acute lower respiratory infection

Interventions

Intervention1: Adaptive support ventilation mode: Mode of ventilation with closed loop communication Control Intervention1: PSIMV+PS mode of ventilation: Mode of ventilation with open loop communicati

Sponsors

Post Graduate institute of medical education and research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Children between one month to 12 years of age 2. On mechanical ventilation.

Exclusion criteria

Exclusion criteria: 1. Children intubated for upper airway obstruction. 2. Chronic lung disease. 3. Children with air leak syndrome. 4. Moribund child.

Design outcomes

Primary

MeasureTime frame
Duration of mechanical ventilation in adaptive support ventilation vs PS-SIMV mode among critically ill children.Timepoint: At 28 days of ventilation initiation—

Secondary

MeasureTime frame
To compare ASV vs PC-SIMV+PS mode among critically ill children for: Complications: VAP, PEAO, extubation failure, reintubation rates, air leak syndromes. Duration of PICU stay. Mortality. Physicians ease of usage measured as visual analogue scale Timepoint: 28 days of initiation of ventilation—

Countries

India

Contacts

Public ContactUppaluri naga pradeep babu

Postgraduate institute of medical education and research

sureshangurana@gmail.com9855373969

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026