Comparison of epidural space expansion with Inj.Normal Saline 0.9% or Inj. Lignocaine Adrenaline 2% (1:200000) following Spinal Anaesthesia: A Clinical Study

Comparative study to evaluate the effect of expansion of epidural space with Inj. Normal saline 0.9% or Inj. Lignocaine Adrenaline (1:200000) 2% before using Inj. Bupivacaine 0.5% heavy for spinal anaesthesia - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

CTRI

Registry ID

CTRI/2025/04/084695

Enrollment

140

Registered

2025-04-13

Start date

Unknown

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Epidural volume expansion: The epidural space is dilated with either 3cc of Inj.Lignocaine Adrenaline (1:200000) 2% or 3cc of Inj Normal Saline (0.9%) and then sub arachnoid block is pe

Eligibility

Inclusion criteria

Inclusion criteria: Pateints with ASA GRADE I OR II undergoing lower abdomen or lower limb surgeries

Exclusion criteria

Exclusion criteria: Pt refusal, ASA III, ASA IV, active fungal infection, sepsis, severe mitral stenosis, severe aortic stenosis, shock, demyelinating lesions, left ventricular outflow tract obstruction, pregnancy, lactating women, failure of sub arachnoid block

Design outcomes

Primary

Measure	Time frame
Onset of sensory blockade ( T10) Timepoint: every 1 min till first 5 min, every 5 min till first 30 mins, then every 15 mins till end of surgery	—

Secondary

Measure	Time frame
Onset of motor blockade ( bromage 1) Maximum level of sensory blockade attained and the time taken for the same. Maximum level of motor blockade attained and time taken for the same. Time for two segments sensory regression. Hemodyanamic changes adverse effects duration of sensory and motor blockTimepoint: every 1 min till first 5 min, every 5 min till first 30 mins, then every 15 mins till end of surgery	—

Measure

Time frame

Onset of motor blockade ( bromage 1) Maximum level of sensory blockade attained and the time taken for the same. Maximum level of motor blockade attained and time taken for the same. Time for two segments sensory regression. Hemodyanamic changes adverse effects duration of sensory and motor blockTimepoint: every 1 min till first 5 min, every 5 min till first 30 mins, then every 15 mins till end of surgery

—

Countries

India

Contacts

Public ContactDr. Sukriti Atram

Grant Government Medical College and Sir JJ Hospital

sukritiatram@yahoo.co.in9004083034

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026