Evaluating the Use of VExUS along with Standard Care for Guiding fluid removal therapy in Children Aged 5-18 with Acute Kidney Injury: A Pilot Study

Performance of VExUS with standard of care versus standard of care as guide for decongestive therapy in children with AKI in the age group of 5-18 Years A Pilot, feasibility randomised control trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/084654

Enrollment

Registered

2025-04-13

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N17- Acute kidney failure

Interventions

Intervention1: Venous excess ultrasound(VExUS) is a bed side diagnostic test used to evaluate the systemic venous congestion in children with AKI: VExUS is a non invasive bed side doppler evalaution

Eligibility

Inclusion criteria

Inclusion criteria: Children aged 5 to 18 years with acute kidney injury (AKI) admitted in Pediatric department of AIIMS Bhopal

Exclusion criteria

Exclusion criteria: i. All children with who are eligible, whose parents refuse to give written informed consent. ii. Children diagnosed with CKD stage 3 or above. iii. All children who are already diagnosed with chronic liver disease, Budd Chiari syndrome, moderate to severe tricuspid regurgitation, chronic pulmonary hypertension. iv. All children who anatomical abnormality of liver v. All children with renal vascular abnormality, gross hydronephrosis and cystic kidney disease vi. All children who had received RRT prior to hospital admission

Design outcomes

Primary

Measure	Time frame
Renal replacement therapy free days during the initial 28 days in children with Acute Kidney Injury Mortality in children with Acute Kidney injury in both groupsTimepoint: 28 days after diagnosis of AKI in child	—

Secondary

Measure	Time frame
To evaluate the correlation of VExUS score with need of RRT Timepoint: Initial 28 days after diagnosing Acute kidney injury in child;To evaluate the requirement of total diuretic dose in both groupsTimepoint: Initial 7 days after diagnosing Acute kidney injury in child;Cumulative fluid overload in both the group at the end day 7 of enrolmentTimepoint: Initial 7 days after diagnosing Acute kidney injury in child;To evaluate the occurrence Intradialytic hypotension in children with AKI receiving RRT in both groupTimepoint: Initial 7 days after diagnosing Acute kidney injury in child;To evaluate the proportion of children with AKI developing dyselectrolytemia (in terms of sodium, potassium and calcium disturbances) in both groups.Timepoint: Initial 7 days after diagnosing Acute kidney injury in child	—

Measure

Time frame

To evaluate the correlation of VExUS score with need of RRT Timepoint: Initial 28 days after diagnosing Acute kidney injury in child;To evaluate the requirement of total diuretic dose in both groupsTimepoint: Initial 7 days after diagnosing Acute kidney injury in child;Cumulative fluid overload in both the group at the end day 7 of enrolmentTimepoint: Initial 7 days after diagnosing Acute kidney injury in child;To evaluate the occurrence Intradialytic hypotension in children with AKI receiving RRT in both groupTimepoint: Initial 7 days after diagnosing Acute kidney injury in child;To evaluate the proportion of children with AKI developing dyselectrolytemia (in terms of sodium, potassium and calcium disturbances) in both groups.Timepoint: Initial 7 days after diagnosing Acute kidney injury in child

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Countries

India

Contacts

Public ContactDR AMBER KUMAR

AIIMS BHOPAL

drgcbhatt@gmail.com8462002229

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026