Comparing pulpal anesthesia among Preheate, Cooled, buffered and Conventional 2 Percentage Lignocaine in teeth With Symptomatic irreversible pulpitis

COMPARATIVE EVALUATION OF PULPAL ANESTHESIA AND PAIN DURING INJECTION USING IANB WITH PREHEATED VERSUS COOLED VERSUS BUFFERED AND CONVENTIONAL 2% LIGNOCAINE IN TEETH WITH SYMPTOMATIC IRREVERSIBLE PULPITIS A RANDOMIZED CLINICAL STUDY - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/084635

Enrollment

120

Registered

2025-04-11

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: 2 percentage lignocaine with 1:80,000 epinephrine preheated to 42 degree celsius: As Local anesthetic in inferior alveolar nerve block Intervention2: 2 percentage lignocaine with 1:80,0

Eligibility

Inclusion criteria

Inclusion criteria: 1,Patients in good health (ASA classification Class I). 2.Patients capable of providing informed consent. 3.Patients diagnosed with dental caries in mandibular molars, presenting with symptomatic irreversible pulpitis, with or without apical periodontitis. 4.Patients without allergies to anesthetic agents. 5.Patients with a VAS score between 0 to 10 6.Patients not consuming any medications that interact with anesthetic agents. 7.Patients without pathosis in the areas considered for injection.

Exclusion criteria

Exclusion criteria: 1.Patients showing no response to cold tests. 2.Teeth with periradicular lesions (excessive PDL widening). 3.Asymptomatic teeth or VAS scores in the range of 1 to 3 4.Teeth with nonvital coronal pulp during the preparation of the access cavity (partial necrosis). 5.Patients with a history of significant medical conditions (ASA Class II or higher). 6.Patients taking any medications that may affect pain assessment.

Design outcomes

Primary

Measure	Time frame
1)Achievement of profound pulpal anesthesia in irreversible pulpitis 2)Onset of actionTimepoint: 1)Achievement of profound pulpal anesthesia in irreversible pulpitis - 10 - 15 minutes after inferior alveolar nerve block 2)Onset of action - 10 - 15 minutes after inferior alveolar nerve block	—

Secondary

Measure	Time frame
Pain during injectionTimepoint: 10 - 15 minutes after inferior alveolar nerve block	—

Countries

India

Contacts

Public ContactDR.P SHAKUNTHALA

Tamilnadu government dental college

shaksmds03@gmail.com9940394135

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026