Health Condition 1: I509- Heart failure, unspecified Health Condition 2: I501- Left ventricular failure, unspecified
Conditions
Interventions
Intervention1: Cardiac resynchronization therapy using using fusion-optimized interval (FOI) programming: Followed up for 6 months after CRT implantation
Control Intervention1: Cardiac resynchronizati
Sponsors
Dr Bhargav Somaiya
Eligibility
Inclusion criteria
Inclusion criteria: Patients with standard indication of cardiac resynchronization 1.Ejection fraction less than or equal to 35% 2.QRS duration greater than or equal to 130ms 3.Left bundle branch morphology 4.New York Heart Association Functional Class II, III and ambulatory class IV 5.Optimal medical treatment 6.With preserved intrinsic AV conduction
Exclusion criteria
Exclusion criteria: 1.Patient refusal 2.Cardiomyopathy with a reversible cause 3.Patients planned for heart transplantation 4.Atrial fibrillation 5.Complete AV block 6.AV delay greater than 250 ms 7.Right bundle branch block 8.Other diseases with less than 1 year life expectancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the change in electrocardiographic dys-synchrony with LV function changes in the form of QRS narrowing and fragmentation on ECG & Echocardiographic response of more than 15% decrease in LV-ESV (Left Ventricular-End Systolic Volume) and more than 5% increase in LV ejection fraction (LV-EF).Timepoint: At baseline and 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in 6 minute walk testTimepoint: 6 months;Changes in NYHA classTimepoint: 6 months;Changes in BNP/NT-proBNP levelsTimepoint: 6 months | — |
Countries
India
Contacts
Public ContactProf Nitish Naik
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed