Health Condition 1: L638- Other alopecia areata
Conditions
Interventions
Intervention1: Efficacy of topical tofacitinib versus in localized alopecia areata.: Patients with localized alopecia areata over scalp with SALT score S1, more than 5 years, having stable disease.Res
Sponsors
AIIMS Jodhpur
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients who are clinically diagnosed with localized alopecia areata over scalp. 2. SALT score S1(less than 25 percent hair loss). 3. Age group more than 5 years. 4. Stable disease without appearance of new patch or increase in size of existing patch in last 15 days and without evidence of spontaneous hair regrowth.
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating females. 2. Patients who have received any topical treatment within the last 2 weeks or systemic corticosteroids, immunosuppressants, or oral tofacitinib in the past month. 3. Patch with atrophy or active infection at the site of patch. 4. Alopecia totalis, alopecia universalis, ophiasis, sisaipho pattern and alopecia areata involving sites other than scalp. 5. Patients with history of HIV, Hep B, Hep C, TB, leucopenia, hepatic and renal impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hair regrowth score (RGS) at end of 4 months.Timepoint: Baseline, 4 weeks, 8 weeks, 12 weeks, 16 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Number of patients having more than 50% improvement in RGS score. 2. Percentage reduction in area involved with alopecia areata in both the groups. 3. Change in SALT score 4. DIMT classification for patterns of regrowth 5. Patient satisfaction score 6. Improvement in trichoscopy parameters 7Quality of life of patients using Dermatology Life Quality Index (DLQI) 8.Side effects in both groups. 9.To assess relapse (if any) in both the groups. Timepoint: Baseline, 4 weeks, 8 weeks, 12 weeks, 16 weeks | — |
Countries
India
Contacts
Public ContactSukarna Saha
All India Institute of Medical Science, Jodhpur
Outcome results
None listed