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A study to compare efficacy of calcium hydroxide versus non antibiotics as intra canal medicament

Comparative evaluation of anti microbial efficacy and post operative pain after using calcium hydroxide, lignocaine, lignocaine with ibuprofen, lignocaine with diclofenac as intra canal medicament in teeth with symptomatic apical periodontitis - A randomised control trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/04/084565
Enrollment
56
Registered
2025-04-11
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K045- Chronic apical periodontitis

Interventions

Intervention1: Lignocaine: Intra canal medicament for 7 days Intervention2: Lignocaine with Diclofenac: intra canal medicament for 7 days Intervention3: Lignocaine with Ibuprofen: Intra canal medicame

Sponsors

Uma Bharathi B
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1)Patients with age group 17-45 years of either gender presenting non vital tooth with symptomatic apical periodontitis of maxillary central incisor. 2) Patients with no systemic disease. 3)Periodontally healthy individuals 4)Patients with good oral hygiene. 5)Patients with pre operative pain scores ranging from moderate to severe (4-10) on a Visual Analog Scale 6)Patients willing for voluntary participation & have signed informed Consent.

Exclusion criteria

Exclusion criteria: 1)Tooth with calcified pulp chambers 2) Open apices 3)Root canal retreatment cases 4) Patients under antibiotic medications 5)Grossly decayed tooth 6)Root resorption 7)Root caries 8)Fractures 9)Previous endodontic treatment 10)Allergic reaction to lignocaine , ibuprofen , diclofenac 11)Patients who have taken analgesic or anti inflammatory drugs within 12 hours pre operatively 12)Patient with contributory medical history 13) Pregnant women

Design outcomes

Primary

MeasureTime frame
Reduction in intra canal microbial countTimepoint: one week for reduction in microbial count

Secondary

MeasureTime frame
Reduction in post operative painTimepoint: 48 hours for post operative pain

Countries

India

Contacts

Public ContactDrRAMAPRABHA B

Tamilnadu government dental college

isharamah@gmail.com9940666344

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026