Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis Health Condition 2: K80- Cholelithiasis
Conditions
Interventions
Intervention1: Tablet Melatonin: Melatonin (N-acetyl-5-methoxytryptamine) is an endogenous sleep regulating hormone secreted by pineal gland. Exogenous administration of melatonin facilitates sleep on
Sponsors
Hamdard Institute of Medical Sciences and Research
Eligibility
Inclusion criteria
Inclusion criteria: This prospective, randomized, double-blind study will be conducted on 70 patients undergoing laparoscopic cholecystectomy under general anaesthesia.
Exclusion criteria
Exclusion criteria: 1.Patient not consenting 2.Known or anticipated difficult airway 3.Morbid Obesity 4.History of mental illness 5.Known Allergy to the study drug 6.History of GERD 7.Patient on Antipsychotic, Sedatives, Anxiolytics, Antiepileptics 8.Patient having History of Sleep Disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| compare the effect of oral melatonin premedication versus placebo on changes in Systolic Blood Pressure following intubation.Timepoint: Baseline in Operation theatre, After induction, before intubation, after intubation, 1 minute post intubation, 3 minute post intubation, 5 minute post intubation, 10 minute post intubation, creation of pneumoperitneum | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)To compare the effects of oral melatonin premedication on changes in Diastolic Blood Pressure, Mean Arterial Pressure and heart rate following intubation between the groups. 2)To compare the propofol dose required for induction of general anaesthesia 3)To compare the intraoperative requirement of isoflurane and fentanyl Timepoint: Baseline in Operation theatre, After induction, before intubation, after intubation, 1 minute post intubation, 3 minute post intubation, 5 minute post intubation, 10 minute post intubation, creation of pneumoperitneum | — |
Countries
India
Contacts
Public ContactRia Tyagi
Outcome results
None listed