Health Condition 1: K044- Acute apical periodontitis of pulpal origin Health Condition 2: E119- Type 2 diabetes mellitus without complications
Conditions
Interventions
Intervention1: intervention-I-PRF with hydroxyapatite
: Autologous i-PRF is derived from the patient s own blood &
mixed with hydroxyapatite (HA)which enhance bone regeneration
Control Intervention1
Sponsors
Dr Surbhi Patel
Eligibility
Inclusion criteria
Inclusion criteria: 1) All the patients for this study will be uncontrolled diabetic patients in which HbA1c is above and equal to 8 which will be used for the preparation of autologous injectable platelet rich fibrin 2)healthy Volunteers having HbA1c between 4.0-5.6 which will be used for the preparation of homologous injectable platelet rich fibrin
Exclusion criteria
Exclusion criteria: 1) Smokers or patients on anti-coagulant or anti-inflammatory therapy in past 4 weeks 2) Patients with blood dyscrasias, on immunosuppressant drugs, and alcoholics. 3) Pregnant and lactating mothers. 4) Patients having any acute infection, heart failure, and malignancy at the time of blood sampling insufficient blood/platelet count (platelet count less than 100,000 per mm).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Enhanced periapical healing as evidenced by radiographic reduction in periapical lesion size over a specified follow-up period.Timepoint: At baseline and 6 and 9 month intervals | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparative efficacy of homologous versus autologous i-PRF in promoting healing. Timepoint: Broader Implications: The study may validate the use of advanced biomaterials in addressing the healing challenges associated with diabetes, potentially leading to more predictable endodontic outcomes | — |
Countries
India
Contacts
Public ContactDr .Surbhi Patel
SPDC Wardha
Outcome results
None listed