Evaluating the rate of recurrence of nasal polyps after sinus surgery if we give steroid both by mouth and nose versus by only nose

A randomized control trial evaluating dual therapy of oral corticosteroids versus intranasal corticosteroids only to prevent recurrence in chronic rhinosinusitis with nasal polyposis after functional endoscopic sinus surgery - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/04/084442

Enrollment

Registered

2025-04-09

Start date

Unknown

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J329- Chronic sinusitis, unspecified

Interventions

Intervention1: Systemic and intranasal steroid: Along with intranasal steroids in the post surgery patients, systemic steroids will be given to one arm. Recurrence rates will be compared based on clin

Eligibility

Inclusion criteria

Inclusion criteria: Willing to participate in the study, Cases of CRSwNP or recurrent cases of CRSwNP

Exclusion criteria

Exclusion criteria: Cases of AFRS, Patients in whom systemic steroids are contraindicated (both absolute and relative)

Design outcomes

Primary

Measure	Time frame
To compare clinicoradiological recurrence in two arms as per SNOT22 criteria clinically, as per Lund Kennedy staging endoscopically and as per Lund Mackay staging radiologicallyTimepoint: Preoperatively, 6 weeks, 3 months, 6 months	—

Secondary

Measure	Time frame
To evaluate role of Absolute eosinophil count, Serum periosteum levels and serum Ig E levels in predicting recurrenceTimepoint: Preoperatively, 6 weeks 3months and 6 months post surgery	—

Countries

India

Contacts

Public ContactPratishtha Sathi

All India Institue of Medical Sciences, New Delhi

winirk@hotmail.com9868397461

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026