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Association cognitive impairment and depression in Type 2 diabetes mellitus

Association of Wnt signaling pathway and neuroinflammation during cognitive impairment and depression in Type 2 diabetes mellitus: a case control study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/04/084353
Enrollment
128
Registered
2025-04-08
Start date
Unknown
Completion date
Unknown
Last updated
2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E119- Type 2 diabetes mellitus without complications

Interventions

Intervention1: NIL: NIL

Sponsors

Atiya Sahar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged between 18 to 60 years of T2DM with HbA1c greater than 6.5 or taking anti diabetic medications with minimum duration of 5 years of diagnosis and Healthy volunteers without T2DM.

Exclusion criteria

Exclusion criteria: Any individuals with Type 1 diabetes. Patients with any significant comorbidities. Any patients with history of recent viral infection like HIV or hepatitis or others. Pregnant or lactating women patients and any patient taking alcohol or any drug abuse.

Design outcomes

Primary

MeasureTime frame
Assessment of cognitive impairment depression and quality of life in Type 2 diabetes mellitus patientsTimepoint: Single time point—

Secondary

MeasureTime frame
Investigation of Wnt signaling biomarkers Wnt1 PORCN Rspo2 and neuroinflammatory markers IL6 IL1beta and TNFalphaTimepoint: Single time point;Association of Wnt1 PORCN Rspo2 with neuroinflammation and the risk of developing cognitive impairment depression and its effect of quality of life in type 2 diabetes mellitus patientTimepoint: Single time point—

Countries

India

Contacts

Public ContactDr Nidhi

Jamia Hamdard

nidhiagarwal@jamiahamdard.ac.in9818334770

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026