Health Condition 1: H186- Keratoconus
Conditions
Interventions
Intervention1: Riboflavin containing Vitamin E Tocopheryl Polyethylene Glycol Succinate(TPGS): These patients will undergo accelerated
Transepithelial corneal cross linking using 9mW/cm2
of continuous
Sponsors
Poppy Debbarma
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age 18 years or above 2. Thinnest pachymetry of 360 micrometer or above on Pentacam 3. K-max of 65D or less onScheimpflug imaging with Pentacam 4. Grade 1-3 keratoconus by Belin ABCD classification on Pentacam. 5. Corrected distance visual acuity (CDVA) of less than 20/20 on the Snellen vision chart 6. Endothelial cell density of 2000 cells/mm2 or above 7. Absence of any ocular surface disorders and other active ocular allergic conditions
Exclusion criteria
Exclusion criteria: 1. Presence of advanced keratoconus associated with subepithelial scarring 2. History of herpetic keratitis or recurrent corneal erosions 3. Previous corneal surgery 4. Previous history of cross linking 5. Presence of any corneal guttae or other endothelial pathology. 6. Patients who are pregnant or breast feeding. 7. Patients with autoimmune diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Demarcation line depth and visibility to be measured on Swept source OCT at 8 weeks after the CXL procedure procedureTimepoint: 8 weeks after the CXL procedure | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Change in total corneal densitometry at 3 months & 6 months post CXL compared to pre CXL values Timepoint: 3 months & 6 months;2. Change in maximum keratometry(Kmax) 3 months & 6 months after CXL compared to pre CXL values Timepoint: 3 months & 6 months;3. Change in total corneal Higher order aberrations at 3 months & 6 monthsTimepoint: 3 months & 6 months | — |
Countries
India
Contacts
Public ContactPoppy Debbarma
Post Graduate Institute of Medical Education and Research
Outcome results
None listed