Health Condition 1: G939- Disorder of brain, unspecified Health Condition 2: G94- Other disorders of brain in diseases classified elsewhere
Conditions
Interventions
Intervention1: Conventional Awake Extubation of Endotracheal Tube: After completion of craniotomy surgery under general anaesthesia ,patient is extubated in the conventional manner.
Intervention2: I-G
Sponsors
Rukmani Birla Hospital
Eligibility
Inclusion criteria
Inclusion criteria: With consent for the procedure, ASA grade 1 & 2,Age group 18 to 60 years,Modified Mallampati grade 1 and 2, Undergoing general anaesthesia for elective craniotomy surgeries,Tumor size less than 4cm,Aneurysm,Modified Fischer grade 1 or 2,Surgical duration less than 4 hours,Blood loss less than 400ml,Fasting greater than or equal to 8 hours,BMI less than 30
Exclusion criteria
Exclusion criteria: Refusal to give consent,History of allergic drug reaction to any of the proposed drugs set to be used during the procedure,Patients with anticipated difficult intubation,Glasgow coma score less than 15, ASA grade 3,4 and 5, Patients with signs of increased ICP Volumes greater than 1.5ml per kg on ultrasound guided gastric antrum examination, History of congestive heart failure, uncontrolled hypertension, uncontrolled diabetes mellitus, acute respiratory distress syndrome, psychiatric illness, bleeding disorder, hepatic or renal dysfunction Patients who may need elective mechanical ventilation post operatively Patients who are receiving IV beta blockers Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in Heart Rate,Systolic Blood Pressure, Diastolic Blood Pressure and Mean Arterial Blood Pressure.Timepoint: The parametres were measured At the end of surgery, After reversal, 1 minute after reversal, 3 minutes after reversal, 5 minutes after reversal, 10 minutes after reversal, 15 minutes after reversal,1 hour post operatively and 6 hours post operatively. | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the total doses of intravenous Diltiazem required in each group to maintain hemodynamic parameters (Heart Rate & Mean Arterial Pressure) within 20% of baseline values during the extubation period. To evaluate the incidence of respiratory complications following withdrawal of general anaesthesia, such as bucking, coughing, desaturation, laryngospasm, & pulmonary edema.Timepoint: Intravenous Diltiazem will be administered At the end of surgery, after reversal, 1 minute after reversal,3 minutes after reversal, 5 minutes after reversal, 10 minutes after reversal & 15 minutes after reversal. | — |
Countries
India
Contacts
Public ContactDR HUDA SUBAIR
RUKMANI BIRLA HOSPITAL, A UNIT OF CMRI , JAIPUR
Outcome results
None listed