Health Condition 1: E888- Other specified metabolic disorders
Conditions
Interventions
Intervention1: Resveratrol: Resveratrol 500mg/day for 90 days(3months)
Control Intervention1: NIL: NIL
Sponsors
NIL
Eligibility
Inclusion criteria
Inclusion criteria: Men and women of age 60-75 years. If diabetic, should be on stable oral hypoglycemic medications for at least 3 months. If hypertensive, on stable anti-hypertensive medications for at least 3 months. Willing to give written informed consent.
Exclusion criteria
Exclusion criteria: Severe respiratory or cardiac dysfunction. Abnormally elevated liver enzymes ALT and or AST more than tree times ULN. eGFR less than thirty ml per min Elevated creatinine phosphokinase CPK more than three times ULN. Chronic alcoholic or drug abuse subjects. Known cases of malignancy and HIV infection. Use of antioxidant supplements. Use of Hormone replacement therapy. History of significant head injury or any major surgery. Previous use of resveratrol in the past three months. Severe cognitive impairment or dementia. Subject who participated in any other clinical investigation using an experimental drug in the past three months. Participants who are not willing to attend treatment schedule regularly
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess then effect of resveratrol on sirtuin 1 during the study period Gradual recovery from symptomsTimepoint: Measurement of sirtuin 1 on day 0, day 45 and day 90 | — |
Secondary
| Measure | Time frame |
|---|---|
| To find out the MoCa score improvement Six-minute Walk test (6MWT) Quality of life measurement (EuroQol-5D-5L Questionnaire) To evaluate adverse events during the study period To evaluate treatment adherenceTimepoint: Assessment of MoCa score, six-minute walk test, EuroQol 5D 5L Questionnaire on day 0, day 45, day 90 | — |
Countries
India
Contacts
Public ContactSubhiksha S
SRM hospital and research centre,SRM IST
Outcome results
None listed